Occupational health issues of commercial vehicle drivers have become increasingly prominent. In the post-pandemic era, health demands continue to upgrade. Intelligent health cockpits have become an important development direction for commercial vehicle technology. Based on ergonomics, environmental engineering and intelligent sensing technology, this paper systematically analyzes the health risks of commercial vehicle cabins in dimensions such as air quality, microbial control, human-machine interaction and intelligent environmental monitoring, and proposes a closed-loop health guarantee system architecture covering "monitoring-purification-protection-interaction". This paper focuses on discussing the realization paths of core technologies such as real-time monitoring of multi-source pollutants, intelligent fresh air purification, intelligent perception of drivers' physiological states, and personalized health management. It also combines the dynamics of industry standards and the actual operational scenario requirements to provide theoretical references for the technological upgrading of the industry.